The Lowdown on Linkage Disequilibrium
نویسندگان
چکیده
منابع مشابه
The Lowdown on Linkage Disequilibrium
Flowering time varies among Arabidopsis accessions. Some of the genes that contribute to this polygenic trait have been localized using quantitative trait loci (QTL) mapping, eventually leading to the identification of genetic variants that contribute to observed differences in flowering time (El-Assal et al., 2001). Despite this and other similar successes with the positional cloning of QTL, t...
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Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...
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The Earth’s early environment was relatively poor in oxygen, and observations and modeling indicate that the rise in oxygen levels did not occur until long after oxygen-enriching bacterial photosynthesis had developed. Catling et al. (p. 839; see the Perspective by Kasting) explain the apparent disconnect between oxygenation and the start of photosynthesis by adding methanogenesis to the proces...
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1. Abstract 2. Introduction 3. Models and methods 3.1. Haplotype block characterization 3.2. Measure of haplotype block LD 3.3. Test statistic and power calculation 3.4. Population genetic model of haplotype block 4. Results 4.1. Haplotype block LD measure 4.2. Power of the haplotype block LD mapping 4.3. Mapping 5. Discussion 6. Appendix 6.1. Appendix A 6.2. Appendix B 6.3. Appendix C 7. Refer...
متن کاملHomozygosity and linkage disequilibrium.
We illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various linkage disequilibrium measures. They feature a clear ...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 2003
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.150730